Yeah, there were lots of options (and some really great ones!) that could totally make up for a lot of things Disquiet and Wasteland do, but I’m mostly thinking about how Wasteland eventually changes their surroundings to try and kill them and how that would effect a static grid.
There would be ways to do it as long as you heavily focused on that as an element of the game as a whole–and some of those ways are probably really interesting–but I’m not sure how much fun it would be in an open game like City of Glass or similar.